a Record control number 000246468100011

a ISSN 0022-3492

a Original cataloging agency NEU GrandLibrary

a Language code of text/sound track or separate title eng

a Classification number WU 29

b Item number .E34 2007

a Personal name Aras, Hamit.

h Medium Electronic Document

a Title Effect of systemically administered naproxen sodium on clinical parameters and myeloperoxidase and elastase-like activity levels in gingival crevicular fluid

c Statement of responsibility, etc Hamit Aras, Feriha Caglayan, Guliz N. Guncu, Atilla Berberoglu, Kamer Kilinc.

c Date of publication, distribution, etc 2007.

b Name of publisher, distributor, etc Amer acad periodontology,

a Summary, etc Background: The present study was conducted to determine the possible effect of naproxen sodium on clinical status and the enzymatic profile of gingival crevicular fluid (GCF) when given as adjunct to periodontal treatment. Methods: A total of 34 subjects with chronic periodontitis were selected and divided into two groups to receive either naproxen sodium or placebo. At baseline, GCF samples were obtained and probing depths (PID), gingival index (GI), plaque index (PI), and gingival bleeding index (GBI) scores were recorded. In the non-steroidal anti-inflammatory drug (NSAID) group, patients were treated with a protocol consisting of baseline periodontal treatment (scaling, root planing) and naproxen sodium (275 mg) administration daily for 6 weeks. In the placebo group, patients received the same treatment except placebo was given instead of naproxen sodium. At the end of the experimental period, clinical recordings and GCF sampling were repeated. Myeloperoxidase (MPO) and elastase-like enzyme activity (ELA) levels were determined in GCF samples by a spectrophotometric method. GCF enzymatic content was calculated both as total enzyme activity and enzyme concentration. Results: All of the clinical parameters, except mean GBI, were significantly lower in the experimental group (P<0.05). At baseline and at the end of the experimental period, there were no significant differences between the NSAID and placebo groups regarding GCF MPO and ELA levels in either mode of data presentation (P<0.05). However, in the NSAID group, mean ELA concentration (P= 0.002) and mean total ELA (P = 0.003) presented significant decreases with treatment. Also, with treatment, a general reduction in MPO levels was seen; however, this difference was not significant. Although constant and stable correlations between GCF enzyme levels and clinical parameters could not be found, positive and strong correlations were observed between total enzyme activity and enzyme concentrations. Conclusion: Based on the positive clinical effect and the ELA profile of GCF, it can be suggested that NSAIDs given as an adjunct to baseline periodontal treatment could be beneficial in the outcome of treatment

a Topical term or geographic name as entry element Dentistry

a Topical term or geographic name as entry element Near East University Article

a Topical term or geographic name as entry element Yakın Doğu Üniversitesi Makale

a Main entry heading Journal of periodontology

g Relationship information MAY 2007, Vol 78 Issue 5, p868-873

x International Standard Serial Number 00223492

u Uniform Resource Identifier http://library.neu.edu.tr:2048/login?url=http://dx.doi.org/10.1902/jop.2007.060412